个人详细情况

    刘极龙，男，1982年2月出生于辽宁省丹东市宽甸县，理学博士，讲师。    刘极龙，1982年生。2002年进入东北农业大学生物科学理科基地八年制本硕博连读班，2011年博士毕业。2011年毕业后在汕头大学理学院生物系进行教学科研工作，讲 师。2013年转入beat365。

    自2006年以来，一直从事哺乳动物胚胎着床的分子机制研究。最近5年，以第一作者或通讯作者身份发表在JBC、PLOS one、Reproductive Sciences等杂志发表SCI论文7篇，单篇引用最高为17次。

学历及培训经历：

2002年09月-2011年06月 东北农业大学生命科学学院 “本硕博”连读

工作经历：

2013年07月—至今        beat365  讲师

2011年07月—2013年07月  汕头大学理学院生物系  讲师

研究领域：

·生殖生物学：筛选子宫对胚胎着床接受性相关的分子标记，以及研究胚胎着床和子宫蜕膜化的分子机理。

·生物信息学：通过基因芯片、蛋白组学、大规模并行测序等高通量方法并结合开发新的生物信息学算法、软件和数据库来研究胚胎着床过程。

·非编码RNA：主要兴趣在于研究非编码RNA的功能及作用机理

承担科研项目情况：

主持国家自然科学基金2项：

1. 国家自然科学基金面上项目，31271602，《甲状腺激素脱碘酶DIO3在小鼠胚胎着床过程中的调节与功能》，2012/08-2016/12，88万 ，结题，主持

2. 国家自然科学基金面上项目，31771665，《XIST基因在小鼠子宫衰老过程中的作用和机制研究》，2018/01-2021/12，58万 ，在研，主持

参与国家自然科学基金6项：

1. 国家自然科学基金青年项目，31501206，《Snail在着床、内膜重建、异位症中的功能及作用机制》，2015/08-2018/12, 20万元, 在研，参与

2. 国家自然科学基金面上项目，31572475，《microRNA在两性胸腺差异性退化中的作用及其基因调控网络研究》，2015/08-2019/12，76.8万元，在研，参与

3. 国家自然科学基金面上项目，31471397，《胚胎着床和蜕膜化过程中多胺的调节及功能》，2014/08- 2018/12，85万元，在研，参与

4. 国家自然科学基金面上项目，31272263，《小鼠子宫中谷胱甘肽过氧化物酶3（GPX3）的调节及其与蜕膜化的关系》，2012/08-2016/12，90万，结题，参与

6. 国家自然科学基金重点项目，30930013，《小鼠胚胎着床过程中信号转导和转录激活因子3的作用机理》，2010/01-2013/12，191万，结题，参与

代表论著：（*通讯作者）

[1] M. Zhao, W.Q. Zhang, J.L. Liu*, A study on regional differences in decidualization of the mouse uterus, Reproduction, 153 (2017) 645-653.

[2] J.L. Liu*, W.Q. Zhang, M. Zhao, M.Y. Huang, Integration of Transcriptomic and Metabolomic Data Reveals Enhanced Steroid Hormone Biosynthesis in Mouse Uterus During Decidualization, Proteomics, 17 (2017).

[3] J.L. Liu*, W.Q. Zhang, M.Y. Huang, Transcription start site-associated small RNAs in the PTEN gene, Proceedings of the National Academy of Sciences of the United States of America, (2017). (Letter)

[4] Y. Li, Z.L. Kang, N. Qiao, L.M. Hu, Y.J. Ma, X.H. Liang, J.L. Liu, Z.M. Yang, Effects of Excess Copper Ions on Decidualization of Human Endometrial Stromal Cells, Biological trace element research, 177 (2017) 10-15.

[5] J.L. Liu*, R.J. Zuo, Y. Peng, Y.S. Fu, The Impact of Multiparity on Uterine Gene Expression and Decidualization in Mice, Reproductive sciences (Thousand Oaks, Calif.), 23 (2016) 687-694.

[6] J.L. Liu*, M. Zhao, Y. Peng, Y.S. Fu, Identification of gene expression changes in rabbit uterus during embryo implantation, Genomics, 107 (2016) 216-221.

[7] J.L. Liu*, M. Zhao, Prioritization of Susceptibility Genes for Ectopic Pregnancy by Gene Network Analysis, International journal of molecular sciences, 17 (2016).

[8] J.L. Liu*, M. Zhao, A PubMed-wide study of endometriosis, Genomics, 108 (2016) 151-157.

[9] J.L. Liu*, T.S. Wang, M. Zhao, Genome-Wide Association Mapping for Female Infertility in Inbred Mice, G3 (Bethesda, Md.), 6 (2016) 2929-2935.

[10] X.H. Liang, W.B. Deng, Y.F. Liu, Y.X. Liang, Z.M. Fan, X.W. Gu, J.L. Liu, A.G. Sha, H.L. Diao, Z.M. Yang, Non-coding RNA LINC00473 mediates decidualization of human endometrial stromal cells in response to cAMP signaling, Scientific reports, 6 (2016) 22744.

[11] R.J. Zuo, X.W. Gu, Q.R. Qi, T.S. Wang, X.Y. Zhao, J.L. Liu, Z.M. Yang, Warburg-like Glycolysis and Lactate Shuttle in Mouse Decidua during Early Pregnancy, The Journal of biological chemistry, 290 (2015) 21280-21291.

[12] T.S. Wang, F. Gao, Q.R. Qi, F.N. Qin, R.J. Zuo, Z.L. Li, J.L. Liu, Z.M. Yang, Dysregulated LIF-STAT3 pathway is responsible for impaired embryo implantation in a Streptozotocin-induced diabetic mouse model, Biology open, 4 (2015) 893-902.

[13] Q.R. Qi, X.Y. Zhao, R.J. Zuo, T.S. Wang, X.W. Gu, J.L. Liu, Z.M. Yang, Involvement of atypical transcription factor E2F8 in the polyploidization during mouse and human decidualization, Cell cycle (Georgetown, Tex.), 14 (2015) 1842-1858.

[14] J.L. Liu*, T.S. Wang, M. Zhao, Y. Peng, Y.S. Fu, A Transcriptomic Study of Maternal Thyroid Adaptation to Pregnancy in Rats, International journal of molecular sciences, 16 (2015) 27339-27349.

[15] J.L. Liu*, T.S. Wang, Systematic Analysis of the Molecular Mechanism Underlying Decidualization Using a Text Mining Approach, PloS one, 10 (2015) e0134585.

[16] J.L. Liu*, Y. Peng, Y.S. Fu, Efficient prediction of progesterone receptor interactome using a support vector machine model, International journal of molecular sciences, 16 (2015) 4774-4785.

[17] W.B. Deng, X.H. Liang, J.L. Liu, Z.M. Yang, Regulation and function of deiodinases during decidualization in female mice, Endocrinology, 155 (2014) 2704-2717.

[18] R.W. Su, B. Jia, H. Ni, W. Lei, S.L. Yue, X.H. Feng, W.B. Deng, J.L. Liu, Z.A. Zhao, T.S. Wang, Z.M. Yang, Junctional adhesion molecule 2 mediates the interaction between hatched blastocyst and luminal epithelium: induction by progesterone and LIF, PloS one, 7 (2012) e34325.

[19] J.L. Liu, X.H. Liang, R.W. Su, W. Lei, B. Jia, X.H. Feng, Z.X. Li, Z.M. Yang, Combined analysis of microRNome and 3'-UTRome reveals a species-specific regulation of progesterone receptor expression in the endometrium of rhesus monkey, The Journal of biological chemistry, 287 (2012) 13899-13910.

[20] W. Lei, X.H. Feng, W.B. Deng, H. Ni, Z.R. Zhang, B. Jia, X.L. Yang, T.S. Wang, J.L. Liu, R.W. Su, X.H. Liang, Q.R. Qi, Z.M. Yang, Progesterone and DNA damage encourage uterine cell proliferation and decidualization through up-regulating ribonucleotide reductase 2 expression during early pregnancy in mice, The Journal of biological chemistry, 287 (2012) 15174-15192.

[21] A.G. Sha, J.L. Liu, X.M. Jiang, J.Z. Ren, C.H. Ma, W. Lei, R.W. Su, Z.M. Yang, Genome-wide identification of micro-ribonucleic acids associated with human endometrial receptivity in natural and stimulated cycles by deep sequencing, Fertility and sterility, 96 (2011) 150-155.e155.

[22] J.L. Liu, Z.M. Yang, Non-coding RNAs and embryo implantation, Frontiers in bioscience (Elite edition), 3 (2011) 1092-1099.

[23] J.L. Liu, R.W. Su, Z.M. Yang, Differential expression profiles of mRNAs, miRNAs and proteins during embryo implantation, Frontiers in bioscience (Scholar edition), 3 (2011) 1511-1519.

[24] R.W. Su, W. Lei, J.L. Liu, Z.R. Zhang, B. Jia, X.H. Feng, G. Ren, S.J. Hu, Z.M. Yang, The integrative analysis of microRNA and mRNA expression in mouse uterus under delayed implantation and activation, PloS one, 5 (2010) e15513.

[25] Y.C. Zhao, Y.J. Chi, Y.S. Yu, J.L. Liu, R.W. Su, X.H. Ma, C.H. Shan, Z.M. Yang, Polyamines are essential in embryo implantation: expression and function of polyamine-related genes in mouse uterus during peri-implantation period, Endocrinology, 149 (2008) 2325-2332.

[26] S.J. Hu, G. Ren, J.L. Liu, Z.A. Zhao, Y.S. Yu, R.W. Su, X.H. Ma, H. Ni, W. Lei, Z.M. Yang, MicroRNA expression and regulation in mouse uterus during embryo implantation, The Journal of biological chemistry, 283 (2008) 23473-23484.

[27] X.H. Ma, S.J. Hu, H. Ni, Y.C. Zhao, Z. Tian, J.L. Liu, G. Ren, X.H. Liang, H. Yu, P. Wan, Z.M. Yang, Serial analysis of gene expression in mouse uterus at the implantation site, The Journal of biological chemistry, 281 (2006) 9351-9360.

写给学生的话：

　　导师易作，有胸怀肯担当足矣，哪怕庸而不昏；学生难为，有本领有豪情不够，仍需下笨功夫。